John Wheeler was born in Connecticut but moved to Indiana in 1847. He settled in Lake County, Indiana where he worked as a farmer and teacher. He and his father worked at draining swamplands in the region. He was elected County Surveyor in 1853 and later established a newspaper called the Crown Point Register.
Colonel Wheeler's name is inscribed on the 20th Indiana's regimental monument located near the site where he fell. The Colonel John Wheeler Middle School in Crown Point is also named in his honor.