John Mayhew

• John Mayhew (musician), drummer for the progressive rock band Genesis
• John Mayhew (cricketer), English cricketer
• John W. Mayhew, former head football coach at Louisiana State University
• John Mayhew (Conservative politician), British politician, MP for East Ham North, 1931–1945
• John Mayhew, 18th-century London cabinet-maker, see Ince and Mayhew
• John Mayhew (doctor), New Zealand sports physician, North Harbour team doctor formerly chief medical official to the New Zealand national rugby union team