John Markley


John L. Markley is an American biochemist.
Markley focuses on NMR spectroscopy and its biological applications, structure function relationships in proteins, stable-isotope-assisted multinuclear magnetic resonance spectroscopy, processing and analysis of multi-dimensional NMR data; structural genomics and metabolomics.
Marley is currently the Steenbock Professor of Biomolecular Structure at the University of Wisconsin–Madison and an Elected Fellow of the American Association for the Advancement of Science.

Research publications

Source:
2020Dashti H, Westler WM, Wedell JR, Demler OV, Eghbalnia HR, Markley JL, Mora S. Probabilistic identification of saccharide moieties in biomolecules and their protein complexes. Scientific Data. 7: 210. DOI: 10.1038/s41597-020-0547-y
2020Aceti DJ, Ahmed H, Westler WM, Wu C, Dashti H, Tonelli M, Eghbalnia H, Amarasinghe GK, Markley JL. Fragment screening targeting Ebola virus nucleoprotein C-terminal domain identifies lead candidates. Antiviral Research. 104822. DOI: 10.1016/j.antiviral.2020.104822
2020Alhajala HS, Markley JL, Kim JH, Al-Gizawiy MM, Schmainda KM, Kuo JS, Chitambar CR. The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1. Oncotarget. 11: 1531-1544. DOI: 10.18632/oncotarget.27567
2020Cai K, Frederick RO, Markley JL. 2mISCU interacts with NFU1, and ISCU transfers its Fe-S cluster to NFU1 leading to the production of holo-NFU1. Journal of Structural Biology. 107491. DOI: 10.1016/j.jsb.2020.107491
2020Barnett BR, Fathi F, Falco Cobra P, Yi SY, Anderson JM, Eghbalnia HR, Markley JL, Yu JJ. Metabolic Changes in Synaptosomes in an Animal Model of Schizophrenia Revealed by H and H,C NMR Spectroscopy. Metabolites. 10. DOI: 10.3390/metabo10020079
2020Romero PR, Kobayashi N, Wedell JR, Baskaran K, Iwata T, Yokochi M, Maziuk D, Yao H, Fujiwara T, Kurusu G, Ulrich EL, Hoch JC, Markley JL. BioMagResBank as a Resource for Structural Biology. Methods in Molecular Biology. 2112: 187-218. DOI: 10.1007/978-1-0716-0270-6_14
2020Weber DK, Wang S, Markley JL, Veglia G, Lee W. PISA-SPARKY: an interactive SPARKY plugin to analyze oriented solid-state NMR spectra of helical membrane proteins. Bioinformatics. DOI: 10.1093/bioinformatics/btaa019
2020Tanrikulu IC, Westler WM, Ellison AJ, Markley JL, Raines RT. Templated Collagen "Double Helices" Maintain Their Structure. Journal of the American Chemical Society. DOI: 10.1021/jacs.9b07583
2020Lee W, Tonelli M, Frederick RO, Haruta M, Cornilescu G, Cornilescu CC, Sussman MR, Markley JL. Solution Structure Determination of Arabidopsis Thaliana RALF8 Illustrates the use of Cutting-Edge Software Developed at the National Magnetic Resonance Facility at Madison Biophysical Journal. 118: 62a. DOI: 10.1016/j.bpj.2019.11.514
2019Bortnov V, Tonelli M, Lee W, Lin Z, Annis DS, Demerdash ON, Bateman A, Mitchell JC, Ge Y, Markley JL, Mosher DF. Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum. Nature Communications. 10: 5612. DOI: 10.1038/s41467-019-13577-5