James Cain
James or Jim Cain may refer to:
- James H. Cain, Methodist minister in Melbourne, Australia
- James M. Cain, American journalist and novelist
- James P. Cain, politically appointed American diplomat
- Jim Cain (defensive end), American player of gridiron football
- Jim Cain (tackle), Canadian football player
- Jim Cain (ice hockey), Canadian ice hockey player
- James Cain (Isle of Man politician), Manx Speaker of the House of Keys
- James D. Cain Jr., United States federal judge
- J. V. Cain, tight end