Jessie Smith

• Jessie Payne Margoliouth, née Smith, Syriac scholar
• Jessie Willcox Smith, American illustrator
• Jessie Evans Smith, wife of Joseph Fielding Smith
• Jessie Maye Smith, American ornithologist
• J. L. Smith, American baseball pitcher
• Jessie Carney Smith, American librarian and educator
• Jessie Smith , American R&B vocalist