Jean Chmielewski


Jean Chmielewski is an American chemist who is the Alice Watson Kramer Distinguished Professor at Purdue University. Her research considers drug discovery, nanobiotechnology and the cellular delivery of therapeutic agents. She was awarded the 2025 American Chemical Society Francis P. Garvan–John M. Olin Medal.

Education

Chmielewski received her Bachelor of Science degree at Saint Joseph's University in 1983. Her undergraduate research developed prostaglandin oligomerization. She moved to Columbia University for her graduate studies, where she developed biomimetic chemistry with Ronald Breslow. She completed her National Institutes of Health Postdoctoral Fellowship in 1990 at Rockefeller University and the University of California, Berkeley. At Rockefeller, Chmielewski was awarded an NIH postdoctoral fellowship, and worked with Emil T. Kaiser on peptide fragment coupling. At the University of California, Berkeley, Chmielewski developed covalent methods to stabilize peptide conformations.

Career

Chmielewski began her tenure as a professor at Purdue University. Her early work looked to transform enzyme inhibitors for HIV/AIDS. She looks to create antibiotics that target intracellular pathogenic bacteria and agents that modulate drug efflux transporters.

Achievements and awards