James Vaughan

• James Vaughan, Dean of Achonry, Ireland, from 1662 to 1683
• James Vaughan , British magistrate
• James David Vaughan, American musician
• James Churchill Vaughan, Nigerian physician
• James H. Vaughan, Canadian politician
• James J. Vaughan, American composer
• James Vaughan, English right-back
• James Vaughan, English footballer for Tranmere Rovers
• James Vaughan, chief constable of Dorset Police
• James Vaughan, creator of the video game ''Plague Inc.''