James Vaughan

• James Vaughan (priest), Dean of Achonry, Ireland, from 1662 to 1683
• James Vaughan (magistrate), British magistrate
• James David Vaughan, American musician
• James Churchill Vaughan, Nigerian physician
• James H. Vaughan, Canadian politician
• James J. Vaughan, American composer
• James Vaughan (footballer, born 1986), English right-back
• James Vaughan (footballer, born 1988), English footballer for Tranmere Rovers
• James Vaughan (police officer), chief constable of Dorset Police
• James Vaughan, creator of the video game ''Plague Inc.''