James Sharples

• James Sharples (portrait painter), English portrait painter and pastelist
• James Sharples (blacksmith), English blacksmith and self-taught artist and engraver
• James Sharples (cricketer), English cricketer who played for Glamorgan
• Sir James Sharples (police officer), chief constable of Merseyside Police
• James Sharples (bishop), Coadjutor Vicar Apostolic of the Lancashire District