James Otis

• James Otis Sr., Massachusetts lawyer and public official
• James Otis Jr., American revolutionary politician from Massachusetts
• James Otis , mayor of San Francisco, California
• James Otis , member of the New York State Senate and a society leader during the Gilded Age
• James C. Otis, Justice of the Minnesota Supreme Court
• Jim Otis, American football player
• James Otis, pen name of James Otis Kaler, American journalist and children's author