James Nichols

• James D. Nichols, American jockey
• James Nichols, convicted for the 2007 murder of Cha Vang in Wisconsin
• James P. Nichols, recording industry producer and engineer
• James Nichols , English printer and theological writer
• James Edward Nichols, Welsh geneticist
• James Douglas Nichols, American farmer, brother of Terry Nichols, convicted Oklahoma City Bombing accomplice
• James W. Nichols, American farmer and politician