James Lyon
James Lyon may refer to:
- James E. Lyon, American businessman and Texas Republican politician
- James Lyon, 7th Earl of Strathmore and Kinghorne
- James Lyon , early American music composer
- Sir James Frederick Lyon, British Army officer and Governor of Barbados, 1829–33
- James R. Lyon, American merchant and soldier, Wisconsin Republican politician
- James M. Lyon, American computer programmer, co-author of the INTERCAL programming language