James Knowles
James Knowles may refer to:
- James Sheridan Knowles, Irish dramatist and actor
- James Thomas Knowles, English architect
- James Thomas Knowles, English architect and editor of The Nineteenth Century
- James Knowles , World War I ace
- James Knowles , English footballer
- James Knowles , Irish schoolteacher and lexicographer, father of James Sheridan Knowles
- Jim Knowles , defensive coordinator at Penn State University
- Jim Knowles, manager of Tranmere Rovers, 1936–1939
- Jimmy Knowles , baseball player
- James Knowles, Ku Klux Klan member responsible for the lynching of Michael Donald
- James Knowles III, mayor of Ferguson, Missouri
- James Hinton Knowles, British missionary to Kashmir
- Jimmy Knowles , English footballer playing for Accrington Stanley F.C.