James Gillespie

• James Gillespie , U.S. Congressman from North Carolina
• James Gillespie , Scottish minister and theologian
• James Gillespie , Scottish footballer
• James Gillespie , Scottish snuff and tobacco merchant
• James Gillespie, HM Excise officer and commander of the cutter Henry Dundas
• James J. Gillespie, member of the Iowa Senate
• James U. Gillespie, member of the Florida House of Representatives