James Cuffe
James Cuffe may refer to:
- Sir James Cuffe (died 1678), Irish MP for Mayo 1661, grandfather of
- James Cuffe (died 1762), Irish MP for Mayo 1742–61, father of
- James Cuffe, 1st Baron Tyrawley, Irish MP for Mayo 1768–97, for Donegal Borough 1776–77, for Tuam 1783, and peer, father of
- James Cuffe (died 1828), Irish MP for Tralee 1819–28