James Cain
James or Jim Cain may refer to:
- James H. Cain, Methodist minister in Melbourne, Australia
- James M. Cain, American journalist and novelist
- James P. Cain, politically appointed American diplomat
- Jim Cain , American player of gridiron football
- Jim Cain , Canadian football player
- Jim Cain , Canadian ice hockey player
- James Cain , Manx Speaker of the House of Keys
- James D. Cain Jr., United States federal judge
- J. V. Cain, tight end