IsobucaineIsobucaine is a local anesthetic.SynthesisThe reductive amination between aminomethyl propanol and isobutanal afforded N-Isobutyl-1,1-dimethyl-2-hydroxyethanamine, . Acylation of the amine with benzoyl chloride hypothetically goes initially to the amide. The acid catalysis used in the reaction leads to an N to O acyl migration to afford isobucaine.