Isaac Komnenos
Isaac Komnenos may refer to:
- Isaac I Komnenos, Byzantine general and emperor in 1057–1059
- Isaac Komnenos , nephew of Isaac I Komnenos and elder brother of Alexios I
- Isaac Komnenos , son of Byzantine emperor Alexios I Komnenos and Irene Doukaina
- Isaac Komnenos , son of Byzantine emperor John II Komnenos and Piroska of Hungary
- Isaac Komnenos of Cyprus