Indatuximab ravtansine

Indatuximab ravtansine is an immunomodulator and antineoplastic antibody-drug conjugate.
It is the anti-CD138 chimerized MAb linked to the maytansinoid DM4.
It is being investigated as part of a treatment for multiple myeloma.

Clinical trials

Multiple Myeloma

Preliminary data has been reported in 2013 from an early stage clinical trial in combination with Lenalidomide and Dexamethasone. Follow up data reported "encouraging efficacy" in December 2014.

Other

, it is in clinical trials for triple negative metastatic breast cancer and metastatic urinary bladder cancer.

Mechanism of action

CD138 is highly overexpressed on various solid tumors and in hematological malignancies, and represents one of the most specific target antigens for identification of multiple myeloma cells. The antibody part binds to CD138 on the target cells and then the DM4 kills the cell.