Imiloxan

Imiloxan is a drug which is used in scientific research. It acts as a selective antagonist for the Alpha-2B [adrenergic receptor|α_2B] adrenergic receptor, and has been useful for distinguishing the actions of the different α₂ adrenergic subtypes.

Synthesis

The imidazole portion of imiloxan is prepared by the reaction of an imidate with the diethyl acetal of aminoacetaldehyde. N-Alkylation of the imidazole with ethyl iodide gives imiloxan.