Iain Mattaj
Iain William Mattaj FRS FRSE is a British scientist and Honorary Professor at Heidelberg University in Germany. From 2005 to 2018 he was Director General of the European Molecular Biology Laboratory. He stepped down from the position at the end of 2018 following his appointment to Human Technopole. In January 2019 he took office as the first Director of Human Technopole, the new Italian institute for life sciences in Milan, Italy.
Education
Prof. Mattaj has a degree in biochemistry from the University of Edinburgh and he obtained a PhD from the University of Leeds in 1980 for research on cloned Glutamate dehydrogenase genes supervised by John Wooton.He carried out his postdoctoral research at the Friedrich Miescher Institute and then at the Biocentre, University of Basel. There he worked in the laboratory of Eddy De Robertis and established the research areas he would continue to pursue. In 1985 he moved to EMBL where he took up the position of Group Leader at the Heidelberg Laboratory. In the following years he became Coordinator of the Gene Expression Unit and then Scientific Director of EMBL until his appointment as Director General of EMBL.
Research
Mattaj has made a number of important contributions to our knowledge concerning how RNA and proteins are transported between the cell nucleus and cytoplasm. These findings stemmed from his early work on the import and export of ribonucleoproteins — RNA–protein complexes — to and from the cell nucleus.Prof. Mattaj subsequently uncovered the role of enzymes known as GTPases in the regulation of mitosis — the division of the cell nucleus into two daughter nuclei. Under the influence of Ran, a GTPase signaling protein, the cell cytoskeleton remodels to form the mitotic spindle — a crucial structure in mitosis. Ran also has an important role in nuclear envelope assembly at the end of mitosis. By dissecting Ran's role in facilitating mitosis, Iain is enabling researchers to create improved cell-regeneration therapies.