ISS (disambiguation)
- Air Italy (2005–2018)
- Cassini–Huygens
- I.S.S. (film)
- IIS (disambiguation)
- ISIS (disambiguation)
- ISS (2000 video game)
- ISS A/S
- ISS Hockey
- ISS International School
- IShowSpeed
- Idea Star Singer
- Idiopathic short stature
- Incredible Shrinking Sphere
- Independent Subway System
- Injury Severity Score
- Institute for Science and Society
- Institute for Security Studies
- Institute of Social Studies
- Institutional Shareholder Services
- Instituto San Sebastián Yumbel
- Instruction set simulator
- Intercollegiate Socialist Society
- Internal Security Service
- International Seismological Summary
- International Social Service
- International Space Station
- International Staff Songsters of the Salvation Army
- International Superstar Soccer
- Internet Security Systems
- Ion scattering spectroscopy
- Islamic State in Somalia
- Istituto Superiore di Sanità
- Mirror Universe
- Multiple myeloma