Isaac (disambiguation)
- Confessions on a Dance Floor
- Great Isaac Cay, Bahamas
- ISAAC (cipher)
- ISAAC (comics)
- Infrared Spectrometer And Array Camera
- International Society for Analysis, its Applications and Computation
- International Society for Augmentative and Alternative Communication
- International Symposium on Algorithms and Computation
- International Symposium on Symbolic and Algebraic Computation
- Isaac
- Isaac (name)
- Isaac (song)
- Isaac (talk show)
- Isaac Region
- Isaac River
- Isaac's Harbour North, Nova Scotia
- Isaac's Harbour, Nova Scotia
- Isaacs (disambiguation)
- Isaaq
- Ishak (disambiguation)
- Issac, Dordogne
- Izak (disambiguation)
- Izzy (disambiguation)
- Jugdral
- List of storms named Isaac
- Port Isaac
- Zack (disambiguation)