IS-159

IS-159, also known as serotonin-O-carboxymethylglycyltyrosinamide, is a triptan-like serotonin 5-HT_1B and 5-HT_1D receptor agonist which was under development for the treatment of migraine but was never marketed. It is taken intranasally or subcutaneously.
The drug is a small serotonin-containing peptide and is described as being peripherally selective. It acts as a selective and potent serotonin 5-HT_1B and 5-HT_1D receptor agonist. IS-159 has more than 300-fold lower affinity for the serotonin 5-HT_1A receptor and is inactive at the serotonin 5-HT_1E and 5-HT_1F receptors. The drug's pharmacokinetics in humans have been studied.
IS-159 was originated by Immunotech in France and was under development by Immunotech and The Medicines Company in the 1990s and early 2000s, but development was discontinued in 2003. The drug reached phase 2 clinical trials prior to the discontinuation of its development.