IOM
- FN Five-seven
- IOM soybeans
- ISDN-oriented Modular Interface
- Indian Order of Merit
- Infraorbital margin
- Institute of Medicine
- Institute of Medicine, Nepal
- Institute of Occupational Medicine
- Institute of Oriental Manuscripts of the Russian Academy of Sciences
- International One Metre (radiosailing)
- International Organization for Migration
- Intraoperative monitoring
- Isle of Man
- Isle of Man Airport
- Jupiter (mythology)
- SAS (software)
- United States Chamber of Commerce