Interleukin 36 receptor antagonist


Interleukin 36 receptor antagonist is a member of the interleukin-36 family of cytokines. It was previously named Interleukin-1 family member 5.
The protein is known to inhibit the effects of Interleukin-36 cytokines via competing with their receptor IL-36R/IL1RL2 and thereby inhibiting their proinflammatory effects.

Roles in disease

Mutations in the IL-36RN gene resulting in a decrease or production of defective IL-36RA protein have been shown to cause inflammatory skin diseases including generalised pustular psoriasis, acrodermatitis continua suppurativa Hallopeau and acute generalized exanthematous pustulosis.