IFIT2

Interferon-induced protein with tetratricopeptide repeats 2 is a protein that in humans is directed to be produced by the IFIT2 gene. Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein. The IFIT2 gene is one of the many genes that are stimulated by Interferon [type I|type 1 interferons] to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one of the many type 1 interferon-stimulated genes.

Clinical significance

IFIT2 may play a role in preventing tumor progression. Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.