ID-4708

ID-4708 is a butyrophenone neuroleptic agent. It has the same structure as for trifluperidol but differs by the incorporation of an aniline amino group into the butyrophenone sidechain.
Whereas trifluperidol is a Belgian drug developed at Janssen Pharmaceuticals, ID-4708 was developed by a Japanese company called Sumitomo Chemical in the 1970’s.
ID-4708 when given at low doses reduced ambulation, while at higher doses defecation was inhibited.

Synthesis

The chemical synthesis of ID-4708 was reported:

2-Acetylbutyrolactone
4-Fluoro-2-nitrobenzoic acid
4-Fluoro-2-nitrobenzoyl chloride
3-oxolan-2-one
4-Bromo-1-butan-1-one
2--2--1,3-dioxolane
4-hydroxy-4-piperidine

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