Hydroxyethylthiazole kinase
In enzymology, a hydroxyethylthiazole kinase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are ATP and 4-methyl-5-(2-hydroxyethyl)thiazole, whereas its two products are ADP and 4-methyl-5-(2-phosphonooxyethyl)thiazole.
Overview
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-methyl-5-thiazole 2-phosphotransferase. Other names in common use include hydroxyethylthiazole kinase , and 4-methyl-5-thiazole kinase. This enzyme participates in thiamine metabolism. Thiamine pyrophosphate, a required cofactor for many enzymes in the cell, is synthesised de novo in Salmonella typhimurium.In Saccharomyces cerevisiae, hydroxyethylthiazole kinase expression is regulated at the mRNA level by intracellular thiamin pyrophosphate.