Hydramethylnon

Hydramethylnon is an insecticide used primarily in the form of baits for cockroaches and ants. It works by inhibiting Coenzyme Q – [cytochrome c reductase|complex III] in the mitochondrial inner membrane and leads to a halting of oxidative phosphorylation. Some brands of hydramethylnon are Amdro, Blatex, Combat, Cyaforce, Cyclon, Faslane, Grant's, Impact, Matox, Maxforce, Pyramdron, Siege, Scuttle and Wipeout. Hydramethylnon is a slow-acting poison with delayed toxicity that needs to be eaten to be effective.

Toxicology

Hydramethylnon has low toxicity in mammals. The oral is 1100–1300 mg/kg in rats and above 28,000 mg/kg in dogs. Hydramethylnon is toxic to fish; the 96-hour LC₅₀ in rainbow trout is 0.16 mg/L, 0.10 mg/L in channel catfish, and 1.70 mg/L in bluegill sunfish.
Hydramethylnon, when fed to rats for two years, led to an increase in uterine and adrenal tumors at the highest dose; therefore, the United States [Environmental Protection Agency|Environmental Protection Agency] classifies hydramethylnon as a possible human carcinogen.