Human proteome project
The Human Proteome Project is a collaborative effort coordinated by the Human Proteome Organization. Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome.
History
The Human Proteome Organization has served as a coordinating body for many long-running proteomics research projects associated with specific human tissues of clinical interest, such as blood plasma, liver, brain and urine. It has also been responsible for projects associated with specific technology and standards necessary for the large scale study of proteins.The structure and goals of a larger project that would parallel the Human Genome Project has been debated in the scientific literature. The results of this debate and a series of meetings at the World Congresses of the Human Proteome Organization in 2009, 2010 and 2011 has been the decision to define the Human Proteome Project as being composed of two sub-projects, C-HPP and B/D-HPP. The C-HPP will be organized into 25 groups, one per human chromosome. The B/D-HPP will be organized into groups by the biological and disease relevance of proteins.
Projects and groups
The current set of working groups are listed below, in order of the chromosome to be studied.| Chromosome | Group leader | National affiliation |
| 1 | Ping Xu | China |
| 2 | Lydie Lane | Switzerland |
| 3 | Takashi Kawamura | Japan |
| 4 | Yu Ju Chen | Taiwan |
| 5 | Peter Horvatovich | Netherlands |
| 6 | Christoph Borchers | Canada |
| 7 | Edward Nice | Australia, New Zealand |
| 8 | Pengyuan Yang | China |
| 9 | Je-Yoel Cho | Seoul, Korea |
| 10 | Joshua Labaer | USA |
| 11 | Jong Shin Yoo | Korea |
| 12 | Ravi Sirdeshmukh | India, Singapore, Taiwan, Thailand |
| 13 | Young Ki Paik | Korea |
| 14 | Charles Pineau | France |
| 15 | Gilberto B Domont | Brazil |
| 16 | Fernando Corrales | Spain |
| 17 | Gilbert S. Omenn | USA |
| 18 | Alex Archakov | Russia |
| 19 | György Marko-Varga | Sweden |
| 20 | Siqiu Liu | China |
| 21 | Albert Sickmann | Germany |
| 22 | Akhilesh Pandey | USA |
| X | Yasushi Ishihama | Japan |
| Y | Ghasem Hosseini Salekdeh | Iran |
| MT | Andrea Urbani | Italy |
Computational resources
Data reduction, analysis and validation of MS/MS based proteomics results is being provided by Eric Deutsch at the Institute for Systems Biology, Seattle, USA. Data handling associated with antibody methods is being coordinated by Kalle von Feilitzen, Stockholm, Sweden. Overall integration and reporting informatics are the responsibility of Lydie Lane at SIB, Geneva, Switzerland. All data generated as part of HPP contributions are deposited to one of the ProteomeXchange repositories.Current status
The ongoing operations of the chromosome-based Human Proteome Project was the subject of a special issue of the Journal of Proteome Research. The status of the overall project was discussed in an Editorial in that issue.A separate CHPP-wiki has been established by the project's bioinformatics group to maintain current project information, including meetings, events, SOPs and other special resources for the individual chromosome teams.
Metrics for the level of confidence associated with protein observations are a key component of this project. How to define metrics that are meaningful for the variety of experimental protocols being used is a subject of ongoing debate: the current consensus metrics have been published.
Journal articles describing recent status of the project and announcing the launch of the "MissingProteinPedia" can be found here.