Holland–Frei Cancer Medicine

Holland–Frei Cancer Medicine is a medical textbook focused on oncology. It was the first comprehensive textbook about cancer and its treatment that was written in the US.
The first edition was edited by two American physicians, James F. Holland and Emil Frei, and written by themselves plus 158 individual authors. The book itself was a single volume of just over 2,000 pages. Later editions were split into multiple volumes and had more than 300 authors.
Meant to be a comprehensive source, it covers biology of cancer, diagnosis, epidemiology, and its treatment. The disease-specific chapters tend to have relatively little information about the basic biology.

Reception

It has been compared to DeVita's Cancer: Principles and ''Practice of Oncology and Souhami's Oxford Textbook of Oncology'', with each having its strengths and weaknesses. Content about treatments is generally high-quality. In a 2005 review of the sixth edition, Souhami's won greater praise for being evidence-based and providing data than either Holland–Frei's or DeVita's. It has also been criticized for being more focused on US standards instead of global standards.
A perennially popular book, it was listed among the top 10 best-selling cancer reference works in 2004.