Holin superfamily II

The Holin superfamily II is a superfamily of putative pore-forming proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members. The Holin superfamily II includes the TC families:

All four of these families are derived from Pseudomonadota and are of relatively small sizes, the average size of the proteins within the entire superfamily is 78 ± 14 amino acyl residues. Some exceptions can be found. As in holin superfamily I, proteins in these families generally exhibit of 2 transmembrane spanners. Families 1 and 6 in Superfamily II are recognized domains in the Conserved Domains Database (CDD) as Lysis S and PHA00426 superfamilies, respectively, while families 7, and 25 lack recognized conserved domains.