Hippocalcin
Hippocalcin is a protein that in humans is encoded by the HPCA gene.
Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor family of proteins. It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.
Processes
Hippocalcin takes part in the following processes:- Activation of PLD1 and PLD2 expression
- Inhibition of apoptosis
- MAP kinase signalling
- Involved in long term depression in hippocampal neuron
- Required for normal spatial learning
Interactions
- Neuronal apoptosis inhibitory protein
- Mixed lineage kinase 2 – MLK2 is myosin light chain kinase 2
- The b2 adaptin of the AP2 complex
- Calcium-dependent activator protein for secretion