HexobendineHexobendine is a vasodilator that acts as an adenosine reuptake inhibitor.SynthesisHexobendine can be synthesized starting with a reaction between 3,4,5-trimethoxybenzoyl chloride and 3-chloropropanol to give the corresponding ester, 3-chloropropyl 3,4,5-trimethoxybenzoate. The last step involves the reaction between two molar equivalents of 3 with one molar equivalent of 1,2-dimethylethylenediamine completing the synthesis of hexobendine.