Helen Thompson

• Helen Thompson (political economist), English academic
• Helen B. Thompson, American academic
• Helen F. Thompson, American businesswoman and politician
• Helen Harrod Thompson, co-creator of the Family Shelter for Victims of Domestic Violence
• Helen Taylor Thompson, co-founder of Europe's first AIDS hospice
• Helen Thompson (Doctors), a character on the TV series Doctors
• Helen Thompson Gaige, American herpetologist, born Helen Thompson
• Helen Cargill Thompson, Scottish scientist, librarian and art collector