Esuene was appointed Minister of State for Health in July 2005. She was appointed Minister of Environment in January 2006. After a cabinet reshuffle in January 2007, Esuene was given an expanded portfolio as Minister of Environment and Housing. She left office in May 2009 at the end of the Obasanjo administration.
Senate
Helen Essuene was the candidate for the Senatorial seat of Akwa Ibom South in the April 2011 Nigeria general elections, running on the People's [Democratic Party (Nigeria)|People's Democratic Party].