Heart and Soul
- Ben E. King
- Closer (Joy Division album)
- Ein Herz und eine Seele
- Elvis Stojko
- Heart 'n' Soul
- Heart and Soul (1917 film)
- Heart and Soul (1948 film)
- Heart and Soul (AAA song)
- Heart and Soul (Binchy novel)
- Heart and Soul (British TV series)
- Heart and Soul (Exile song)
- Heart and Soul (Five Star album)
- Heart and Soul (Frank Loesser and Hoagy Carmichael song)
- Heart and Soul (Joy Division album)
- Heart and Soul (Kathy Troccoli album)
- Heart and Soul (Kenny G album)
- Heart and Soul (Kenny G composition)
- Heart and Soul (Rosenberg novel)
- Heart and Soul (Steve Brookstein album)
- Heart and Soul (T'Pau song)
- Heart and Soul (Twin Atlantic song)
- Heart and Souls
- Hearts and Souls
- Hearts in Motion
- I Can't Come Down
- In the Heat of the Night (Imagination album)
- Lisa Stanley
- No Sweat (band)
- Pokémon HeartGold and SoulSilver
- Pool It!
- Sarah Hoyt
- Small Change (Prism album)
- Take Them On, On Your Own