HSC
- Halifax Shopping Centre
- Hampden–Sydney College
- Harare Sports Club
- Harmonized System
- Harsco Corporation
- Health Service Commissioner for England
- Health Sponsorship Council
- Health and Safety Commission
- Health and Social Care in Northern Ireland
- Hematopoietic stem cell
- Hepatic stellate cell
- Heraldry Society of Canada
- High-speed craft
- Higher School Certificate (New South Wales)
- Higher School Certificate (UK)
- Higher School Certificate (Victoria)
- Higher Secondary Certificate
- Hillfield Strathallan College
- Hindu Students Council
- Horizon scanning
- Houston Ship Channel
- Hsin Sheng College of Medical Care and Management
- Hughes Systique Corporation
- Huntington Society of Canada
- Hydraulic Sinus Condensing
- Hysteroscopy
- Mass Storage Control Protocol
- Mauser HSc
- Shaoguan Guitou Airport
- Subaru Telescope
- The Hospital for Sick Children, Toronto
- United States Homeland Security Council