HPI
- HP Inc.
- HPI (TV series)
- HPI Groupe
- HPI Ltd
- HPI, LLC
- Happy Planet Index
- Hardware Platform Interface
- Hasso Plattner Institute for Digital Engineering
- Heinrich Pette Institute
- Henley Passport Index
- High probability instruction
- History of the present illness
- House price index
- Huaneng Power International
- Human Poverty Index
- Human performance improvement
- Human probiotic infusion
- Nottawaseppi Huron Band of Potawatomi