HOT-2


HOT-2, also known as 4-ethylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-2, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families. It is the N-hydroxy derivative of 2C-T-2. The drug is taken orally.

Use and effects

In his book PiHKAL, Alexander Shulgin lists HOT-2's dose range as 10 to 18mg orally and its duration as 6 to 10hours. The drug's onset is 30 to 40minutes and peak effects occur after 2hours. HOT-2's properties are very similar to those of 2C-T-2, which has a dose of 12 to 25mg orally, a duration of 6 to 8hours, and an onset of less than 1hour with a time to peak of 1 to 2hours. HOT-2 may act as a prodrug of 2C-T-2.
The effects of HOT-2 have been reported to include some psychedelic visuals like perceptual movement, flowing, and shimmering, increased energy, euphoria, uncomfortableness, easier or more difficult communication, some difficulty concentrating and mental confusion, increased heart rate and blood pressure, and no body load. Shulgin said of HOT-2 that it "seems to be a well tolerated, and generally pleasant material, with a mixture of sensory as well as insightful aspects. Something for everyone."

Interactions

Chemistry

Synthesis

The chemical synthesis of HOT-2 has been described.

Analogues

s of HOT-2 include 2C-T-2, HOT-7, and HOT-17, among others.

History

HOT-2 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL.

Society and culture

Legal status

Canada

HOT-2 is a controlled substance in Canada under phenethylamine blanket-ban language.

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.