HLA-DR53


HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. and the DRB4 locus presence is linked to HLA-DR7 seropositivity. The DRB4*locus was apparently duplicated from an ancestor of the DRB1-DRB4 common locus around 5 million years ago.
DRB4 locus is only apparent in a small subset of DQ haplotypes, and most individuals lack DRB4. In addition the level of normal expression is 8 fold lower than the DRB1 in cells which can express both. and lowered because of both transcriptional and post-transcriptional regulation.

Alleles

DR53 reactive alleles: DRB4*01:01, *01:03
Unknown reactivity: *01:02, *01:04 to *01:07
Null alleles: *01:03:01:02N, 02:01N, *03:01N

Associated diseases

DRB4*01 is positively associated with Erythema multiforme, Crohn's disease, myasthenia gravis, rheumatoid arthritis Hashimoto's thyroiditis, vitiligo, primary biliary cirrhosis, clozapine-induced agranulocytosis, Vogt–Koyanagi–Harada disease,

HLA-DRB1 linkage

HLA-DR53 serotypes is linked to the following HLADR serotypes allele groups:
HLA-DR4 - DRB1*04
HLA-DR7 - DRB1*07
HLA-DR9 - '''DRB1*09'''