HLA-DR16
HLA-DR16 is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.
Alleles
Disease associations
DR16 is associated with Chaga's cardiomyopathy, rheumatic heart disease, coronary artery ectasia, and chronic discoid lupus erythematosus.DRB1*1601 is associated with tuberculosis risk
DRB1*1602: Juvenile rheumatoid arthritis, rheumatic heart disease, , systemic sclerosis & anti-DNA topoisomerase I antibody, melioidosis
Extended linkage
DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk- * *1602:DQA1*0102:DQB1*0502 haplotype: graves disease, cervical cancer, scleroderma
- * *1602:DQA1*05:DQB1*0301 haplotype: rheumatic heart disease, systemic sclerosis
Genetic Linkage