HLA-DR1
HLA-DR1 is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.
Serology
The serology for the most common DR1 alleles is excellent. The serology for alleles,,,,,, and is unknown.Disease associations
By serotype
DR1 is associated with seronegative-rheumatoid arthritis, penicillamine-induced myasthenia, and schizophrenia. DR1 is increased in patients with systemic sclerosis and arthritis and in ulcerative colitis with patients that have articular manifestations.By allele
DRB1*01:01 is associated with rheumatoid arthritis, in anti-Jk mediated hemolytic transfusion reactions, foliaceous pemphigus, HTLV-1-associated myelopathy/tropical spastic paraparesis, and lichen planus. In lyme disease arthritis, *01:01 appears to play a role inpresentation of triggering microbial antigens.
DRB1*01:02 is associated with rheumatoid arthritis, in anti-Jk mediated hemolytic transfusion reactions, psoriasis vulgaris, and recurrent respiratory papillomatosis
DRB1*01:03 is associated with colonic Crohn's disease and ulcerative colitis.
By genotype
DRB1*01:01/*0404 and *01:01/*0401 increases risk of mortality in rheumatoid arthritis, with ischemic heart disease and smoking. these same genotypes are associated with rheumatoid vasculitis.Image:DR beta 1 SEI topdown.JPG|240px|left|ligand within the binding pocket of DR αβ101
By haplotype
DRB1*01:02:DQB1*05:01 is associated with psoriasis vulgaris and tubulointerstitial nephritis & uveitis syndrome, but is relatively protective against juvenile diabetes.DR1-DQ5 is associated with tubulointerstitial nephritis & uveitis syndrome.