HIG1 hypoxia inducible domain family member 1BHIG1 hypoxia inducible domain family member 1B is a protein that in humans is encoded by the HIGD1B gene.FunctionThis gene encodes a member of the hypoxia inducible gene 1 domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants.