HIF1ANHypoxia-inducible factor 1-alpha inhibitor is a protein that in humans is encoded by the HIF1AN gene.InteractionsFIH has been shown to interact with HIF1A and Von Hippel-Lindau [tumor suppressor]. Additionally, asparaginyl hydroxylation of HIF1α by FIH-1 at N803 impairs its interaction with CBP/P300.