Guineesine

Guineesine is a compound isolated from long pepper and black pepper.
It was first isolated, studied and named from Piper guineense.

Research

Guineensine inhibits the cellular reuptake of anandamide and 2-arachidonoylglycerol in a mouse model. This causes an increase in the activity of the two neurotransmitters which are classified as endogenous cannabinoids.
Guineesine can dose-dependently produce cannabimimetic effects in a mouse model which are indicated by potent catatonic, analgesic, hypo-locomotive and hypo-thermic effects. In addition, the analgesic and catatonic effects were reversed by the cannabinoid receptor type 1 inverse agonist rimonabant.
Guineesine is also a monoamine oxidase inhibitor in vitro.