Granule cell dispersion
Granule cell dispersion is one of the abnormal structural changes that has been shown in brains of patients with temporal [lobe epilepsy]. It has also been shown in different animal models, such as the kainic acid model, pilocarpine model, and kindling model. But granule cell dispersion was not found by using perforant pathway stimulation.
It was first described by Houser. In a normal situation, the granule cells in dentate gyrus should be tightly packed. But in granule cell dispersion, the compact formation was lost, and the axons need to extend longer to reach the neighboring granule cells.