Gq-mER

The G_q-coupled membrane estrogen receptor is a G protein-coupled receptor present in the hypothalamus that has not yet been cloned. It is a membrane-associated receptor that is Gq [alpha subunit|G_q-coupled] to a phospholipase C–protein [kinase C]–protein kinase A pathway. The receptor has been implicated in the control of energy homeostasis. G_q-mER is bound and activated by estradiol, and is a putative membrane [estrogen receptor]. A nonsteroidal diphenylacrylamide derivative, STX, which is structurally related to 4-hydroxytamoxifen, is an agonist of the receptor with greater potency than estradiol that has been discovered. Fulvestrant has been identified as an antagonist of G_q-mER, but is not selective.