Gluta macrocarpa grows as a tree up to tall with a trunk diameter of up to. There are buttress roots up to high. The bark is brown to grey and produces latex. The leaves are elliptic or oblanceolate and measure up to long and up to wide, occasionally to long. The flowers are in. The roundish fruits are black to purple and measure up to wide.
Gluta macrocarpa has been assessed as least concern on the IUCN [Red List]. The species' habitat is threatened by deforestation and conversion of land for plantations and agriculture. The species is present in some protected areas.