Maestre's doctoral research focused on the influence of brain genetics on mental health and memory-based diseases, demonstrating that the presence of the Ԑ4 allele of the apolipoprotein gene is related to the risk of Alzheimer's disease. Maestre has led international initiatives to build capacity for research and services aimed at improving prevention and treatment of dementia and other age-related diseases in low-to-middle-income countries, Bolivia, Haiti, and Venezuela. In 2021, she was funded to work on Alzheimer's in the Rio Grande Valley which has a high rate of memory loss among seniors.